San Francisco Giants vs Minnesota Twins Prediction 5/11/25 MLB Picks

In this article, we will formulate a Giants vs Twins prediction for this MLB game on Sunday, May 11, at Target Field in Minneapolis, Minnesota. Let’s take a look at the prediction for this MLB matchup.

San Francisco Giants Betting Preview

The San Francisco Giants (24-16, 12-11 Away) won the series against the Rockies and Cubs, but then scored just two runs in the opening two games of the current series against the Minnesota Twins. The Giants will now try to win Game 3 and avoid being swept for the second time this season. Logan Webb took the loss in the latest 2-1 defeat, after allowing two runs on five hits with nine strikeouts and one walk in 7.0 innings.

This year, the Giants average 4.62 runs per game (7th in the MLB) on a .231/.306/.380 triple-slash. When it comes to pitching, the Giants’ staff has a 3.37 ERA (6th) and 1.21 WHIP (10th). Wilmer Flores leads the Giants with a .245 batting average, seven home runs, and 33 RBI this season.

Landen Roupp will take the mound for the Giants on Sunday. The 26-year-old right-hander has a 2-3 record in seven starts this year with a 4.89 ERA and 1.54 WHIP in 35.0 innings.

Minnesota Twins Betting Preview

The Minnesota Twins (20-20, 14-6 Home) are enjoying their best baseball of the season after winning the last seven games. The Twins beat the Red Sox, swept the Orioles, and defeated the Giants in the first two games of the current series, allowing just two runs in the process. Joe Ryan got the win in the most recent 2-1 victory, after allowing one run on two hits with seven strikeouts and no walks across 6.0 innings of work. Trevor Larnach hit a two-run homer in the 3rd inning, which was enough for the win.

This year, the Twins average 3.92 runs per game (21st in the MLB) on a .235/.305/.371 triple-slash. When it comes to pitching, the Twins’ staff has a 3.29 ERA (5th) and 1.16 WHIP (4th). Byron Buxton leads the Twins with a .271 batting average, nine home runs, and 25 RBI this season.

The projected starting pitcher for the Twins is Pablo Lopez, who is 3-2 in six starts this season, with a 2.18 ERA and 0.94 WHIP in 33.0 innings.

Why the Twins will beat the Giants

• The Twins have won each of their last eight home games.
• The Giants have lost each of their last three games at Target Field.
• The Twins have covered the run line in each of their last eight games at Target Field.
• The Giants have failed to cover the run line in each of their last five games against American League opponents.
• The Giants have trailed after 5 innings in five of their last six games at Target Field.
• The Giants have trailed after 3 innings in each of their last four games at Target Field.

Total Runs Facts

• Each of the Twins’ last seven games as favorites against NL West opponents have gone OVER the total runs line.
• Twelve of the Giants’ last 13 games as road underdogs have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Twins’ last six Sunday games.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in 11 of the Giants’ last 13 games as underdogs against AL Central opponents.

Matchup/League Facts

• The Twins rank 5th in the league for ERA this season (3.29).
• The Twins rank 5th in the league for runs allowed this season (139).
• The Giants rank 6th in the league for hits allowed this season (298).
• The Giants rank 24th in the league for batting average this season (.231).

Giants vs Twins Prediction

The Twins won six of the previous ten H2H encounters, including four of the last six. Minnesota has shown a great defense so far in the series, and that D was the main reason for the recent success and seven straight wins. Pablo Lopez has been excellent this season and hasn’t allowed more than two runs in a game. Lopez allowed a .113 BA in 53 at-bats against the Giants. Landen Roupp, on the other hand, allowed multiple runs in all but one start this season, so I am giving an advantage to the Twins in this one. They will get to Roupp early on and will maintain the lead thanks to a sturdy defense and excellent pitching.

Oliver Zivic's Pick: Twins ML