Milwaukee Brewers vs Cleveland Guardians Prediction 5/12/25 MLB Picks

The Milwaukee Brewers and the Cleveland Guardians meet Monday in MLB action from Progressive Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Milwaukee Brewers vs. Cleveland Guardians prediction.

Starting Pitching Matchup

The Milwaukee Brewers will send out Freddy Peralta for the start here, and Peralta is 4-2 with a 2.18 ERA and 48 strikeouts this season. In his career, Peralta is 1-1 with a 3.27 ERA and 8 strikeouts against the Guardians. Ben Lively will get the nod for the Guardians here and is 2-2 with a 3.46 ERA and 28 strikeouts this season. In his last five starts against the Brewers, Lively is 0-4 with a 3.38 ERA and 21 strikeouts.

Milwaukee Brewers Recap

The Milwaukee Brewers come into this series looking to build on a 4-2 win over the Rays from Sunday’s series finale to avoid the sweep and sit at 20-21 on the year. After this series, the Brewers will head on the road for a series against the Minnesota Twins.

Brewers Snap Three-Game Losing Streak

Brice Turang has 42 hits with 3 home runs, 16 RBIs, and 9 stolen bases, while Jackson Chourio has 45 hits with a team-high 13 doubles, 7 home runs, and 25 RBIs, and Sal Frelick has 36 hits as well as 2 triples and 7 stolen bases so far this season. Christian Yelich also has 8 stolen bases with 7 homers and 26 RBIs while also adding 3 doubles. Yelich also has a team-high 45 strikeouts up to this point in the year. William Contreras has 4 homers and 21 RBIs as well this season.

Why the Milwaukee Brewers will win

• The Brewers have won each of their last 10 night games against AL Central opponents following a win.
• The Guardians have lost each of their last three night games after playing the previous day.
• The Brewers have covered the run line in each of their last seven night games against American League opponents following a road win.
• The Guardians have failed to cover the run line in each of their last six night games at Progressive Field following a home loss.

Milwaukee Brewers Player Prop Facts

• Rhys Hoskins has hit a home run in each of the Brewers’ last two games against AL Central opponents that held a winning record.
• William Contreras has recorded at least one RBI in seven of the Brewers’ last eight games as road favorites.
• Freddy Peralta has recorded eight or more strikeouts in four of his last five appearances against AL opponents that held a winning record.
• William Contreras has scored at least one run in seven of the Brewers’ last eight games as favorites.
• William Contreras has recorded a Single in each of his last seven road appearances against opponents that held a winning record.
• Rhys Hoskins has recorded at least one hit in each of the Brewers’ last six games against AL opponents.
• Freddy Peralta has recorded a win in each of his last three appearances with the Brewers as favorites.
• Freddy Peralta ranks T10th in the league for Wins (4) this season.

Cleveland Guardians Recap

The Cleveland Guardians come into this game looking to rebound from the 3-0 loss they suffered at the hands of the Philadelphia Phillies in Sunday’s rubber match to drop to 23-17 on the year. After this series, the Guardians will head on the road for an interleague series against the Cincinnati Reds.

Guardians Drop Back-To-Back Games

Steven Kwan leads the Guardians with 52 hits as part of a .331 batting average and 4 home runs, 8 doubles, and 17 RBIs. Kyle Manzardo has 25 hits with 3 doubles, a triple, 9 home runs, and a team-high 22 RBIs as well this year. Gabriel Arias has a team-high 7 doubles but also 35 strikeouts, and Manzardo has a team-high 38 strikeouts so far this season. Arias has also added 4 home runs and 16 RBIs, and Jose Ramirez has chipped in 6 home runs and 18 RBIs.

Why the Cleveland Guardians will win

• The Brewers have lost each of their last nine Monday games as road favorites.
• The Guardians have won each of their last six games against NL Central opponents that held a losing record.
• The Brewers have failed to cover the run line in each of their last nine Monday games as road favorites.
• The Guardians have covered the run line each of their last six games against NL Central opponents that held a losing record.

Cleveland Guardians Player Prop Facts

• Carlos Santana has hit a home run in each of the Guardians’ last two night games against opponents that held a losing record.
• Jose Ramirez has recorded at least one Double in each of the Guardians’ last four night games against NL opponents that held a losing record.
• Carlos Santana has recorded at least one RBI in four of the Guardians’ last five games against opponents that held a losing record.
• Carlos Santana has scored at least one run in each of his last six appearances against opponents that held a losing record.
• Jose Ramirez has recorded at least one Single in each of his last seven appearances with the Guardians as underdogs.
• Jose Ramirez has recorded at least one hit in each of the Guardians’ last 10 games against NL opponents.
• Steven Kwan ranks 4th in the league in Hits (52) this season.

Total Runs Facts

• Nine of the Brewers’ last 10 road games against AL Central opponents have gone OVER the total runs line.
• Each of the Guardians’ last four home games against NL Central opponents have gone UNDER the total runs line.

Milwaukee Brewers vs. Cleveland Guardians Prediction

I’m leaning towards the Brewers here. The Guardians were on quite a roll before those losses to Philadelphia to close out the series, and now have arguably their weakest arm in Ben Lively going against the staff ace of the Brewers, and the Brewers, for my money, have just been playing the better baseball over the weekend. I think the edge in starting pitching is too much for Cleveland to overcome, even at home. Give me the Guardians.

Chris Ruffolo's Pick: Milwaukee Brewers -135