Miami Marlins vs Chicago White Sox Prediction 5/11/25 MLB Picks

The Miami Marlins and the Chicago White Sox meet Sunday in MLB action from Rate Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Miami Marlins vs. Chicago White Sox prediction.

Starting Pitching Matchup

The Miami Marlins will send out Sandy Alcantara here for the start and Alcantara is 2-4 with an 8.42 ERA and 23 strikeouts this season. This will be Alcantara’s second career start against the White Sox. Sean Burke will get the nod for the White Sox and is 2-4 with a 4.35 ERA and 27 strikeouts this season. This will be Burke’s first career start against Miami.

Miami Marlins Recap

The Miami Marlins come into this game looking to add on to their 3-1 win over the White Sox last time out to improve to 15-23 on the year. After this series, the Marlins will head on the road for a series against the Cubs.

Marlins Looking For Rare Series Win

Xavier Edwards leads the Marlins with 39 hits including 3 doubles and a team-high 10 stolen bases while Eric Wagaman has 30 hits with 7 doubles. Otto Lopez has 25 hits with 5 doubles and a pair of home runs with 11 RBIs and Matt Mervis has a team-high 7 home runs and 14 RBIs so far this year. Kyle Stowers has 37 hits with 4 doubles, a triple, 7 home runs and 26 RBIs but also has 42 strikeouts while Mervis has 40 K’s as well so far this season.

Why the Miami Marlins will win

• The White Sox have lost each of their last nine Sunday home games against National League opponents.
• The Marlins have won each of their last five day games following a road win.
• The Marlins have covered the run line in each of their last 10 day games against American League opponents.
• The White Sox have failed to cover the run line each of their last five day games against National League opponents that held a losing record.

Miami Marlins Player Prop Facts

• Jesus Sanchez has hit a home run in six of his last 29 appearances with the Marlins against AL opponents.
• Jesus Sanchez has recorded an RBI in three of the Marlins’ last four games.
• Sandy Alcantara has recorded a win in three of his last four appearances with the Marlins as favorites.
• Sandy Alcantara has recorded five or more strikeouts in 13 of his last 15 appearances against AL opponents.
• Otto Lopez has recorded at least one hit in each of his last eight appearances against AL opponents that held a losing record.
• Otto Lopez has recorded at least one Single in each of his last seven appearances against AL opponents that held a losing record.
• Xavier Edwards ranks T8th in the league in Steals (10) this season.

Chicago White Sox Recap

The Chicago White Sox come into this game looking to bounce back from their loss in Saturday’s matchup to fall to 11-29 on the year. After this series, the White Sox will head on the road to take on the Cincinnati Reds for an interleague series.

White Sox Drop 5 Of Their Last 6

Lenyn Sosa leads the White Sox with 36 hits including 6 doubles and 10 RBIs. Andrew Benintendi has 19 hits including 5 home runs, 12 RBIs and a .224 batting average while Miguel Vargas has a team-high 8 doubles and 12 RBIs. Brooks Baldwin has also added 16 RBIs while Luis Robert Jr. has a team-high 15 stolen bases so far this season. Andrew Vaughn has 5 home runs and 16 RBIs as well this season.

Why the Chicago White Sox will win

• The underdogs have won each of the Marlins’ last four games at Rate Field.
• The Marlins have lost four of their last five games as road favorites against AL Central opponents.
• The underdogs have covered the run line in each of the Marlins’ last six games at Rate Field.
• The Marlins have failed to cover the run line in 19 of their last 22 games as favorites.

Chicago White Sox Player Prop Facts

• Andrew Vaughn has recorded an RBI in each of the White Sox’s last four games against NL East opponents that held a losing record.
• Andrew Vaughn has recorded at least one hit in each of the White Sox’s last 10 Sunday games.
• Korey Lee has recorded a Single in each of his last five appearances with the White Sox as underdogs against NL East opponents.
• Andrew Benintendi has scored a run in each of his last five appearances.
• Andrew Benintendi has hit at least one home run in three of his last four appearances at Rate Field against NL opponents that held a losing record.

Total Runs Facts

• Ten of the Marlins’ last 11 road games have gone OVER the total runs line.
• Seven of the White Sox’s last eight home games against NL East opponents have gone UNDER the total runs line.

Miami Marlins vs. Chicago White Sox Prediction

I’m on the Marlins here. I get the case to be made for a home underdog in a lot of spots, but the problem is that the White Sox are still the White Sox. Sandy Alcantara has still struggled for much of the season, but he’s struggled against a lot better than what he’s up against here and if there is a prime spot for Alcantara to find himself and get his form back. I think it’s here. It won’t be a pretty game, but it’ll be effective as I think the Marlins pick up the series win on the road here. Give me Miami in this one.

Chris Ruffolo's Pick: Miami Marlins -135