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Los Angeles Angels vs San Diego Padres Prediction 5/13/25 MLB Picks

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San Diego Padres (25-15) vs Los Angeles Angels (17-23)

May 13, 2025 at 09:40 PM EDT

The Line: Betting Odds: San Diego Padres -205 / Los Angeles Angels +170 — Over/Under: 7.5

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In this article, we will formulate an Angels vs Padres prediction for this MLB game on Tuesday, May 13, at PETCO Park in San Diego, California. Let’s take a look at the prediction for this MLB matchup.

Los Angeles Angels Betting Preview

The Los Angeles Angels (17-23, 8-13 Away) snapped a seven-series losing streak with a win over the Toronto Blue Jays, but returned to losing ways against the Orioles, falling to two of three games. Surprisingly, the Angels beat the Padres 9-5 in Game 1 of the current series in San Diego, thanks to a great 9th inning, in which Los Angeles scored six runs. Taylor Ward blasted a grand slam to lead the offense, while Yusei Kikuchi pitched for 6.0 innings in a no-decision, allowing four runs (two earned) on seven hits with four strikeouts and two walks. Brock Burke was credited with the win.

This season, the Angels average 3.83 runs per game (23rd in the MLB) on a .216/.276/.387 triple-slash. When it comes to pitching, the Angels’ staff has a 5.14 ERA (26th) and 1.49 WHIP (28th). Taylor Ward leads the Angels with a .190 batting average, nine home runs, and 21 RBI this season.

Jose Soriano will take the mound for the Angels on Tuesday. The 26-year-old right-hander has a 2-4 record in eight starts this year with a 4.00 ERA and 1.53 WHIP in 45.0 innings.

San Diego Padres Betting Preview

The San Diego Padres (25-15, 14-5 Home) won three of the previous four starts, including the most recent one against the Colorado Rockies in Denver. They returned home from a three-series road trip and opened the series against the Angels with a 9-5 loss. In that defeat, Michael King pitched for 5.2 innings in a no-decision, allowing three runs (two earned) on four hits with eight strikeouts and two walks. Robert Suarez took the loss.

This year, the Padres average 4.62 runs per game (12th in the MLB) on a .266/.332/.403 triple-slash. When it comes to pitching, the Padres’ staff has a 3.37 ERA (6th) and 1.18 WHIP (6th). Fernando Tatis Jr. leads the Rockies with a .316 batting average, ten home runs, and 24 RBI this season.

The projected starting pitcher for the Padres is Dylan Cease, who is 1-2 in eight starts this season, with a 4.91 ERA and 1.41 WHIP in 40.1 innings.

Why the Padres will cover

  • The Angels have lost nine of their last 10 games following a win.
  • The Padres have won four of their last five home games against the Angels.
  • The Angels have failed to cover the run line in eight of their last nine road games against NL West opponents following a win.
  • The Padres have covered the run line in eight of their last 10 games as home favorites after playing the previous day.
  • The Padres have led after 3 innings in four of their last five games against opponents that held a losing record.
  • The Padres have led after 5 innings in each of their last four home games against AL West opponents that held a losing record.

Total Runs Facts

  • Each of the Padres’ last four games as favorites have gone OVER the total runs line.
  • Nine of the Angels’ last 11 road games against NL West opponents have gone OVER the total runs line.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Padres’ last seven night games against American League opponents.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in four of the Angels’ last five games as underdogs.

Matchup/League Facts

  • The Padres rank 2nd in the league for runs allowed this season (141).
  • The Padres rank 3rd in the league for opponent batting average this season (.219).
  • The Angels rank 29th in the league for hits this season (283).
  • The Angels rank 29th in the league for doubles this season (50).

Angels vs Padres Prediction

The Angeles won six of the previous ten H2H encounters, including the last four. Seven of Los Angeles’s last ten games went Over, which was the case in six of San Diego’s last ten. I have to admit I was a bit shocked by 14 combined runs in Game 1. I was also surprised by Los Angeles’s win, but I am again backing the Padres to win and cover the run line. Dylan Cease had just one off-game this season; otherwise, he has been solid. Cease allowed nine runs in his last five starts and allowed a .172 BA in 58 at-bats against the Angels. Jose Soriano, on the other hand, allowed 3+ runs in four of his previous five starts, so I am giving an advantage to the Padres here.

Oliver Zivic's Pick: Padres -1.5