Los Angeles Angels vs San Diego Padres Prediction 5/12/25 MLB Picks

The Los Angeles Angels are visiting the San Diego Padres on Monday, May 12th at the PETCO Park in the opening game of this series. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Los Angeles Angels vs San Diego Padres Prediction. We will examine:

The San Diego Padres’ recent form and player performance

The Los Angeles Angels’ recent form and player performance

Recent betting trends and streaks involving the San Diego Padres

Recent betting trends and streaks involving the Los Angeles Angels

Recent betting trends in games played between the Los Angeles Angels vs San Diego Padres

A summary that ties it all together and produces a favorable betting outcome for the Los Angeles Angels vs San Diego Padres game

San Diego Padres Preview

The San Diego Padres have a 25-14 record this season and are sitting in second place in the NL West. They have a 14-4 home record and are 17-21 in over/under. The Padres are coming off a 3-9 road defeat by the Colorado Rockies, ending their previous two-game winning streak. Their last three games went over the total, but were played in Coors Field, and were 4-1 to the under in their 5 games before that.

The Padres have a .266 batting average this season, a .332 OBP, and a .403 Slugging percentage. San Diego’s pitching staff has a 3.25 ERA and 1.17 WHIP.  Manny Machado leads the Padres with 47 hits and a team-high .324 batting average. Fernando Tatis Jr leads the team both in RBI, with 23, and in home runs, with 9.  

Michael King (R) will take the mound for the Padres, and he has been dominating this season, following a successful 2024 campaign, with a 4-1 record, 2.22 ERA, and 0.99 WHIP. He has been even better at home, with a 1.32 ERA across five starts. He has only one earned run across 19.2 innings pitched in his last three home starts.  

Los Angeles Angels Preview

The Los Angeles Angels have a 16-23 record this season and are sitting in last place in the AL West. The Angels have a 7-13 road record and 22-17 in over/under. They are coming off a 3-7 road defeat by the Baltimore Orioles, and are 1-3 in their last 4 games. Over is 7-3 in their last 10 games.

The Angels have a .216 batting average this season, a .274 OBP, and a .385 Slugging percentage. LA’s pitching staff has a 5.20 ERA and 1.50 WHIP. Nolan Schanuel leads the Angels with 33 hits, while Mike Trout leads the team with 18 RBI and 9 home runs. Logan O’Hoppe is the team’s best hitter with a .264 batting average.

Yusei Kikuchi (L) will take the mound for the Angels, and he has a 0-4 record, 3.83 ERA, and 1.46 WHIP. He has been significantly weaker on the road, with a 5.19 ERA across five road starts, but he is coming off a quality performance at home, with just one earned run in 6 innings of work, in a 5-4 win over the Toronto Blue Jays. The last time Kikuchi faced the Padres was back in 2020, when he got torched for 8 earned runs across 9 innings of work in two starts.

Why the San Diego Padres will win

• The Angels have lost each of their last nine road games.
• The home team has won each of the last seven games between the Angels and Padres.
• The Angels have failed to cover the run line in each of their last nine road games.
• The home team has covered the run line in each of the last seven games between the Angels and Padres.
• The Angels have trailed after 3 innings in each of their last seven road games.
• The Padres have won the first inning in three of their last four games as favorites.
• The Angels have trailed after 5 innings in each of their last seven road games against NL West opponents that held a winning record.

Why the Los Angeles Angels will win

• The Angels have won each of their last six games as underdogs against NL West opponents following a loss.
• The Padres have lost each of their last six games as favorites against AL West opponents following a road loss.
• The Angels have covered the run line in each of their last six games as underdogs against NL West opponents following a loss.
• The Padres have failed to cover the run line each of their last six night games against American League opponents that held a losing record.
• The Angels have won the first inning in three of their last four games.
• The Padres have trailed after 5 innings in four of their last five games against American League opponents that held a losing record.
• The Padres have trailed after 3 innings in four of their last five night games against American League opponents that held a losing record.

Total Runs Facts

• Seven of the Padres’ last eight games against American League opponents have gone UNDER the total runs line.
• Each of the Angels’ last four road games against National League opponents have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Padres’ last six games against American League opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Angels’ last four games.

Matchup/League Facts

• The Padres rank 1st in the league for batting average this season (.266).
• The Padres rank 1st in the league for strikeouts against this season (265).
• The Angels rank 30th in the league for hits this season (276).
• The Angels rank 30th in the league for on-base percentage this season (.274).

Los Angeles Angels vs San Diego Padres Prediction

The Angels won all three meetings against the Padres last season, but all games were played in LA. The Padres swept their last home series against the Angels back in 2023 with 3-0 wins. Their last four head-to-head meetings had gone under the total.

In this Los Angeles Angels vs San Diego Padres Prediction, the Padres are coming as huge -225 home favorites. The Padres are rightfully favored, as they have been the better team this season and have been one of the best home teams in the MLB, while the Angels are terrible on the road. On top of that, the Angels have the second-worst bullpen in the majors, with a horrendous 6.94 ERA and 1.71 WHIP. The Padres have the pitching advantage, are hitting better, and have a superior bullpen. I expect an easy one for the Padres at home today, so take the San Diego Padres on the runline in this one.

Nikos Lagouretos's Pick: San Diego Padres -1.5