Houston Astros vs Chicago White Sox Prediction 5/2/25 MLB Picks

The Houston Astros are visiting the Chicago White Sox on Friday, May 2nd at the Rate Field in the opening game of this series. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Houston Astros vs Chicago White Sox Prediction. We will examine:

The Chicago White Sox’s recent form and player performance

The Houston Astros’ recent form and player performance

Recent betting trends and streaks involving the Chicago White Sox

Recent betting trends and streaks involving the Houston Astros

Recent betting trends in games played between the Houston Astros vs Chicago White Sox

A summary that ties it all together and produces a favorable betting outcome for the Houston Astros vs Chicago White Sox game

Chicago White Sox Preview

The Chicago White Sox have an 8-23 record this season and are sitting in last place in the AL Central. The White Sox have a 5-10 home record and are 14-14 in over/under. They are coming off an 8-0 home victory over the Milwaukee Brewers, ending their previous three-game losing streak. Over is 4-2 in their last 6 games. The White Sox have a .213 batting average this season, a .299 OBP, and a .329 Slugging percentage. Chicago’s pitching staff has a 4.04 ERA and 1.36 WHIP. Lenyn Sosa leads the White Sox with 29 hits and a team-high .269 batting average. Louis Robert Jr leads the team in RBI, with 13.

Jonathan Cannon (R) will take the mound for the White Sox, and he has a 1-3 record, 4.50 ERA, and 1.44 WHIP. He has been excellent at home, with zero earned runs in 9.1 innings pitched across two starts. In his only previous start against the Astros last season, he had a shutout performance in 8.2 innings pitched.

Houston Astros Preview

The Houston Astros have a 16-14 record this season and are sitting in second place in the AL West. The Astros have a 5-7 road record and 12-16 in over/under. They are coming off a 4-7 home defeat by the Detroit Tigers, ending their previous three-game winning streak. Over is 4-0 in their last 4 games. The Astros have a .236 batting average this season, a .310 OBP, and a .357 slugging percentage. Houston’s pitching staff has a 3.23 ERA and 1.08 WHIP. Jose Altuve leads the Astros with 32 hits and a team-high 4 home runs, while Yordan Alvarez leads the team in RBI with 18. Jeremy Pena is the team’s best hitter, with a .282 batting average.

Framber Valdez (L) will take the mound for the Astros, and he has a 1-3 record, 4.00 ERA, and 1.19 WHIP. He has been weaker on the road with a 4.50 ERA. In his two starts against the White Sox last season, he gave up two earned runs in 13 innings pitched.

Why the Chicago White Sox will win

• The White Sox have won four of their last five games as underdogs against AL West opponents following a home win.
• The Astros have lost three of their last four games as road favorites.
• The White Sox have covered the run line in 13 of their last 14 games as underdogs against AL West opponents following a home win.
• The Astros have failed to cover the run line each of their last five games against teams that held a losing record.
• The Astros have trailed after 5 innings in seven of their last eight games against AL Central opponents.
• The Astros have trailed after 3 innings in four of their last five games.

Why the Houston Astros will win

• The White Sox have lost 12 of their last 13 home games against American League opponents that held a winning record.
• The Astros have won nine of their last 10 games following a loss.
• The Astros have covered the run line in each of their last seven road games against American League opponents following a home loss.
• The White Sox have failed to cover the run line in eight of their last nine home games against teams that held a winning record.
• The Astros have led after 5 innings in 13 of their last 15 games as road favorites against American League opponents.
• The White Sox have trailed after 3 innings in four of their last five home games against American League opponents that held a winning record.
• The White Sox have lost the first inning in three of their last four home games against American League opponents that held a winning record.

Total Runs Facts

• Each of the last six games between the Astros and White Sox at Rate Field have gone UNDER the total runs line.
• Seven of the Astros’ last eight games as favorites against the White Sox have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the White Sox’s last five games.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Astros’ last four night games at Rate Field.

Matchup/League Facts

• The White Sox rank 30th in the league for slugging percentage this season (.329).
• The White Sox rank 29th in the league for hits this season (215).
• The Astros rank 1st in the league for walks allowed this season (82).
• The Astros rank 28th in the league for doubles this season (38).

Houston Astros vs Chicago White Sox Prediction

In their six meetings last season, the Astros led the White Sox 4-2 wins, winning their only series in Chicago by 2-1 wins. Under is 8-1 in their last 9 meetings.

In this Houston Astros vs Chicago White Sox Prediction, the Astros are coming as big -240 road favorites. The Astros are rightfully favored, as they have been the better team this season, but laying such a big number with a team that is below average on the road is not something I am willing to do. Cannon has also looked unhittable at home so far, and Valdez has a 4.50 road ERA, so there is value with the White Sox in the first 5 innings.

You can get the White Sox by +1 run in the F5 innings in a decent price, as I don’t think they will be losing by 2 runs when those two pitchers are on the mound. Take the Chicago White Sox by +1 run in the first 5 innings.