Chicago White Sox vs Cincinnati Reds Prediction 5/13/25 MLB Picks

The Chicago White Sox and Cincinnati Reds meet Tuesday in MLB action at Great American Ball Park. Here’s a Chicago White Sox vs Cincinnati Reds Prediction. This article will include a Chicago White Sox vs Cincinnati Reds Pick.

Chicago White Sox Betting Preview

The Chicago White Sox are 12-29 on the year and play the Cubs, Mariners, and Rangers next. The Chicago White Sox are batting .214 on the season, have a .291 OBP, and a .321 slugging percentage. The Chicago White Sox pitching staff has a 4.10 ERA and a 1.39 WHIP. Lenyn Sosa leads the Chicago White Sox with 36 hits and 10 RBI, while Miguel Vargas and Andrew Vaughn have combined for 58 hits and 29 RBI. 

Jonathan Cannon gets the ball for the Chicago White Sox, and he is 2-4 with a 4.09 ERA and 33 strikeouts this season. This will be Cannon’s first career game against the Cincinnati Reds.

Cincinnati Reds Betting Preview

The Cincinnati Reds are 20-22 on the year and play the Guardians, Pirates, and Cubs next. The Cincinnati Reds are batting .237 on the season, have a .321 OBP, and a .377 slugging percentage. The Cincinnati Reds pitching staff has a 3.75 ERA and a 1.19 WHIP. TJ Friedl leads the Cincinnati Reds with 43 hits and 17 RBI, while Elly De La Cruz and Gavin Lux have combined for 77 hits and 47 RBI.

Andrew Abbott gets the ball for the Cincinnati Reds, and he is 2-0 with a 2.25 ERA and 31 strikeouts this season. This will be Abbott’s second career game against the Chicago White Sox.

Why the Cincinnati Reds will win

• The White Sox have lost each of their last nine night games against NL Central opponents that held a losing record.
• The Reds have won five of their last six home games following a road loss.
• The White Sox have failed to cover the run line in six of their last seven road games following a home win.
• The Reds have covered the run line in five of their last six home games following a road loss.
• The White Sox have trailed after 5 innings in three of their last four games as road underdogs.

Why the Chicago White Sox will win

• The Reds have lost seven of their last eight games as home favorites against AL Central opponents.
• The underdogs have won each of the White Sox’s last three games.
• The Reds have failed to cover the run line in each of their last nine games as home favorites against American League opponents following a loss.
• The road team has covered the run line in each of the last four games between the White Sox and Reds.
• The Reds have trailed after 3 innings in each of their last three night games against AL Central opponents.
• The White Sox have led after 5 innings in four of their last five road games against NL Central opponents.

Cincinnati Reds Player Prop Facts

• Will Benson has hit a home run in each of his last two appearances with the Reds as favorites against AL opponents.
• Spencer Steer has recorded at least one RBI in each of his last seven Tuesday appearances at Great American Ball Park.
• Will Benson has scored a run in each of his last four appearances in night games against teams that held a losing record.
• Gavin Lux has recorded at least one Single in seven of his last eight appearances against AL opponents that held a losing record.
• Tyler Stephenson has recorded two or more hits in each of his last six home appearances after not playing the previous day.
• Jose Trevino has recorded a Double in each of his last three appearances against AL opponents.
• Matt Mclain ranks T10th in the league in Steals (10) this season.

Chicago White Sox Player Prop Facts

• Andrew Vaughn has recorded at least one RBI in four of the White Sox’s last five road games against NL opponents that held a losing record.
• Luis Robert has recorded at least one Single in each of his last four appearances against the Reds.
• Andrew Vaughn has recorded a hit in each of the White Sox’s last seven games against NL opponents.
• Andrew Benintendi has hit at least one home run in three of his last four appearances against NL opponents that held a losing record.
• Andrew Benintendi has scored a run in each of his last five appearances.

Chicago White Sox vs Cincinnati Reds Prediction

As I’ve said all year, the White Sox are a team we’ve faded endlessly these last three years, and it’s not going to stop now. The White Sox have won two straight games just twice this season. In 28.2 road innings, Cannon has a 5.65 ERA and a .267 allowed batting average. No, thanks. The Reds need to take advantage of games like this if they’re going to right the ship. Abbott has allowed seven hits and zero runs in his last nine innings. Abbott has allowed one or fewer runs in four of his first five starts. In nine home innings, Abbott has a 1.00 ERA and .161 allowed batting average. There’s no excuse for the Reds in a series like this. Of course, give me the RL to shave down the juice. 

Randy Chambers's Pick: Cincinnati Reds -1.5