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Arizona Diamondbacks vs San Francisco Giants Prediction 5/14/25 MLB Picks

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San Francisco Giants (25-18) vs Arizona Diamondbacks (22-21)

May 14, 2025 at 03:45 PM EDT

The Line: Betting Odds: San Francisco Giants -110 / Arizona Diamondbacks -110 — Over/Under: 8

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The Arizona Diamondbacks and San Francisco Giants meet Wednesday in MLB action at Oracle Park. Here’s an Arizona Diamondbacks vs San Francisco Giants Prediction. This article will include an Arizona Diamondbacks vs San Francisco Giants Pick.

Arizona Diamondbacks Betting Preview

The Arizona Diamondbacks are 22-21 on the year and play the Rockies, Dodgers, and Cardinals next. The Arizona Diamondbacks are batting .250 on the season, have a .331 OBP, and a .439 slugging percentage. The Arizona Diamondbacks pitching staff has a 4.65 ERA and a 1.34 WHIP. Corbin Carroll leads the Arizona Diamondbacks with 51 hits and 31 RBI, while Josh Naylor and Geraldo Perdomo have combined for 90 hits and 57 RBI. 

Eduardo Rodriguez gets the ball for the Arizona Diamondbacks, and he is 1-3 with a 6.86 ERA and 48 strikeouts this season. Rodriguez is 1-1 with a 5.06 ERA and 18 strikeouts in his career against the San Francisco Giants.

San Francisco Giants Betting Preview

The San Francisco Giants are 25-18 on the year and play the Athletics, Royals, and Nationals next. The San Francisco Giants are batting .235 on the season, have a .309 OBP, and a .385 slugging percentage. The San Francisco Giants’ pitching staff has a 3.45 ERA and a 1.23 WHIP. Jung Hoo Lee leads the San Francisco Giants with 47 hits and 27 RBI, while Heliot Ramos and Willy Adames have combined for 83 hits and 40 RBI.

Jordan Hicks gets the ball for the San Francisco Giants, and he is 1-4 with a 5.82 ERA and 40 strikeouts this season. Hicks is 0-0 with a 3.60 ERA and 23 strikeouts in his career against the Arizona Diamondbacks.

Why the San Francisco Giants will win

  • The Giants have won eight of their last nine home games against NL West opponents following a home win.
  • The Diamondbacks have lost four of their last five games at Oracle Park against teams that held a winning record.
  • The Giants have covered the run line in seven of their last eight games against National League opponents after playing the previous day.
  • The Diamondbacks have failed to cover the run line in four of their last five games.
  • The Diamondbacks have trailed after 5 innings in three of their last four day games at Oracle Park against NL West opponents.

Why the Arizona Diamondbacks will win

  • The Diamondbacks have won each of their last 10 Wednesday road games.
  • The Giants have lost four of their last five games against NL West opponents that held a winning record.
  • The Diamondbacks have covered the run line in 14 of their last 15 day games against NL West opponents following a road loss.
  • The Giants have failed to cover the run line in five of their last six day games against the Diamondbacks at Oracle Park following a home win.
  • The Giants have lost the first inning in six of their last eight games at Oracle Park against NL West opponents that held a winning record.
  • The Giants have trailed after 3 innings in four of their last five home games against opponents that held a winning record.

San Francisco Giants Player Prop Facts

  • Willy Adames has hit a home run in two of his last three appearances at Oracle Park against NL West opponents that held a winning record.
  • Willy Adames has recorded at least one Double in four of his last five appearances against NL West opponents that held a winning record.
  • Jung Hoo Lee has recorded an RBI in four of the Giants’ last five day games.
  • Willy Adames has scored at least one run in each of the Giants’ last four home games.
  • Wilmer Flores has recorded at least one Single in each of his last seven appearances at Oracle Park against NL opponents that held a winning record.
  • Wilmer Flores has recorded at least one hit in each of his last eight appearances against NL opponents.

Arizona Diamondbacks Player Prop Facts

  • Corbin Carroll has hit at least one home run in each of the Diamondbacks’ last three road games against NL West opponents.
  • Josh Naylor has recorded at least one RBI in five of his last six appearances against the Giants after playing the previous day.
  • Alek Thomas has recorded at least one Single in seven of the Diamondbacks’ last eight day games against NL opponents that held a winning record.
  • Corbin Carroll has scored at least one run in 12 of the Diamondbacks’ last 13 road games against NL West opponents.
  • Eduardo Rodriguez has recorded five or more strikeouts in six of his seven previous appearances in day games against NL teams that held a winning record.
  • Lourdes Gurriel Jr. has recorded at least one hit in each of his last 11 appearances at Oracle Park.
  • Jake McCarthy has recorded a Double in three of his last four appearances in day games against NL West teams that held a winning record.
  • Corbin Carroll ranks 3rd amongst qualified players for Slugging Percentage (.620) this season.

Arizona Diamondbacks vs San Francisco Giants Prediction

I’m not looking to back either of these teams given the pitching matchup. Rodriguez looks like a shell of himself, allowing 53 hits and 31 earned runs in 40.2 innings. In 19.2 road innings, Rodriguez has a 7.32 ERA and .326 allowed batting average. He’s allowing a .308 batting average on the season. Hicks has allowed 46 hits and 28 earned runs in 43.1 innings. In 20.1 home innings, Hicks has a 5.75 ERA and .286 allowed batting average. No, thank you. These are two capable lineups as well. I expect some fireworks. Give me the over between the Diamondbacks and Giants. 

Randy Chambers's Pick: Over 8