Arizona Diamondbacks vs San Francisco Giants Prediction 5/13/25 MLB Picks

The Arizona Diamondbacks are visiting the San Francisco Giants on Tuesday, May 13th at the Oracle Park in the second game of this series. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Arizona Diamondbacks vs San Francisco Giants Prediction. We will examine:

The San Francisco Giants’ recent form and player performance

The Arizona Diamondbacks’ recent form and player performance

Recent betting trends and streaks involving the San Francisco Giants

Recent betting trends and streaks involving the Arizona Diamondbacks

Recent betting trends in games played between the Arizona Diamondbacks vs San Francisco Giants

A summary that ties it all together and produces a favorable betting outcome for the Arizona Diamondbacks vs San Francisco Giants game

San Francisco Giants Preview

The San Francisco Giants have a 24-18 record this season and are sitting in third place in the NL West. They have a 12-6 home record and are 24-18 in over/under. They are coming off a 1-2 home defeat by the Diamondbacks, and now have three straight losses. They are 4-1 to the under in their last 5 games, and are playing the Athletics and the Royals next.

The Giants have a .232 batting average this season, a .305 OBP, and a .377 Slugging percentage. San Francisco’s pitching staff has a 3.39 ERA and 1.22 WHIP.  Heliot Ramos leads the Giants with 45 hits and a team-high .290 batting average, while Wilmer Flores leads the team in RBI with 33, and Matt Chapman adds a team-high 8 home runs.

Robbie Ray (R) will take the mound for the Giants, and he has a 5-0 record, 2.84 ERA, and 1.20 WHIP. He has been much better at home, with a 1.80 ERA across 4 home starts. He is coming off back-to-back quality starts, with a total of one earned run in 13 innings of work, and this will be his first start against the D-backs in his career.   

Arizona Diamondbacks Preview

The Arizona Diamondbacks have a 22-20 record this season and are sitting in the 4th place in the NL West. The Diamondbacks have an 11-8 road record and 17-21 in over/under. They are coming off a 2-1 road victory over the Giants and have been alternating wins and losses for the past 10 days. Under is 9-2 in their last 11 games, and are playing the Rockies and the Dodgers next.

The Diamondbacks have a .248 batting average this season, a .330 OBP, and a .438 slugging percentage. Arizona’s pitching staff has a 4.51 ERA and 1.31 WHIP. Corbin Carroll leads the Diamondbacks with 49 hits and a team-high 13 home runs, while Jacob Perdomo leads the team in RBI with 30 and is the team’s best hitter with a .293 batting average.

Brandon Pfaadt (R) will take the mound for the Diamondbacks, and he has a 6-2 record, 3.28 ERA, and 1.22 WHIP. He has been terrible on the road, having given up 11 runs in 16.1 innings of work across three starts, for a 6.06 ERA. He is coming off a shutout performance in 6.1 innings of work against the Dodgers, but in his only start against the Giants last season, he got lit up for 4 earned runs in just 2.2 innings of work, as the Dbacks got destroyed with a 0-11 score.   

Why the San Francisco Giants will win

• The Diamondbacks have lost four of their last five games as favorites following a win.
• The Giants have won seven of their last eight games following a home loss.
• The underdogs have covered the run line in each of the Giants’ last six games.
• The Diamondbacks have failed to cover the run line in each of their last four games against National League opponents following a win.
• The Diamondbacks have trailed after 3 innings in four of their last five road night games.
• The Giants have led after 5 innings in three of their last four home games.

Why the Arizona Diamondbacks will win

• The Giants have lost each of their last nine games as home underdogs.
• The Diamondbacks have won four of their last five games at Oracle Park.
• The Giants have failed to cover the run line in four of their last five home games against teams that held a winning record.
• The Diamondbacks have covered the run line in each of their last four night games against the Giants following a win.
• The Diamondbacks have led after 3 innings in each of their last five games at Oracle Park.
• The Diamondbacks have led after 5 innings in each of their last four night games against the Giants at Oracle Park.
• The Giants have lost the first inning in 10 of their last 13 night games against NL West opponents that held a winning record.

Total Runs Facts

• Eight of the Diamondbacks’ last nine night games after playing the previous day have gone UNDER the total runs line.
• Eight of the Giants’ last nine night games as underdogs have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in nine of the Giants’ last 10 night games at Oracle Park.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in 12 of the Diamondbacks’ last 14 road games against NL West opponents.

Matchup/League Facts

• The Giants rank 3rd in the league for home runs allowed this season (32).
• The Giants rank 24th in the league for batting average this season (.232).
• The Diamondbacks rank 1st in the league for doubles this season (85).
• The Diamondbacks rank T3rd in the league for walks this season (163).

Arizona Diamondbacks vs San Francisco Giants Prediction

The Dbacks are 8-6 in their last 14 meetings against the Giants. Over is 6-2-1 in their last 9 overall meetings, and 4-2-1 in their last 7 meetings in San Francisco.

In this Arizona Diamondbacks vs San Francisco Giants Prediction, the Dbacks are coming as a slight -115 road favorite. The Giants have a better record and have been very strong at home, but they have been in poor form, with four consecutive losses. The Dbacks are just above average on the road and have been up and down for the past 10 days. I trust Ray more at home than I trust Pfaadt on the road, and the Giants have the best bullpen in the MLB to back him up. Add to the fact that this is a bounce-back spot after yesterday’s loss, I will go with the San Francisco Giants on the moneyline in this one.

Nikos Lagouretos's Pick: San Francisco Giants ML